Items where Author is "Wipf, P"

Article

Tandon, M and Salamoun, JM and Carder, EJ and Farber, E and Xu, S and Deng, F and Tang, H and Wipf, P and Wang, QJ (2015) SD-208, a novel protein kinase D inhibitor, blocks prostate cancer cell proliferation and tumor Growth in Vivo by inducing G2/M cell cycle arrest. PLoS ONE, 10 (3).

Adam, C and Baeurle, A and Brodsky, JL and Wipf, P and Schrama, D and Becker, JC and Houben, R (2014) The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma. PLoS ONE, 9 (4).

Greenberger, JS and Berhane, H and Shinde, A and Rhieu, BH and Bernard, M and Wipf, P and Skoda, EM and Epperly, MW (2014) Can radiosensitivity associated with defects in DNA repair be overcome by mitochondrial-targeted antioxidant radioprotectors. Frontiers in Oncology, 4 MAR.

Neal, MD and Jia, H and Eyer, B and Good, M and Guerriero, CJ and Sodhi, CP and Afrazi, A and Prindle, T and Ma, C and Branca, M and Ozolek, J and Brodsky, JL and Wipf, P and Hackam, DJ (2013) Discovery and Validation of a New Class of Small Molecule Toll-Like Receptor 4 (TLR4) Inhibitors. PLoS ONE, 8 (6).

Tandon, M and Wang, L and Xu, Q and Xie, X and Wipf, P and Wang, QJ (2012) A Targeted Library Screen Reveals a New Inhibitor Scaffold for Protein Kinase D. PLoS ONE, 7 (9).

Liu, Z and Celotto, AM and Romero, G and Wipf, P and Palladino, MJ (2012) Genetically encoded redox sensor identifies the role of ROS in degenerative and mitochondrial disease pathogenesis. Neurobiology of Disease, 45 (1). 362 - 368. ISSN 0969-9961

Keffer, JL and Hammill, JT and Lloyd, JR and Plaza, A and Wipf, P and Bewley, CA (2012) Geographic variability and anti-staphylococcal activity of the chrysophaentins and their synthetic fragments. Marine Drugs, 10 (5). 1103 - 1125.

Braunstein, MJ and Scott, SS and Scott, CM and Behrman, S and Walter, P and Wipf, P and Coplan, JD and Chrico, W and Joseph, D and Brodsky, JL and Batuman, O (2011) Antimyeloma effects of the heat shock protein 70 molecular chaperone inhibitor MAL3-101. Journal of Oncology. ISSN 1687-8450

Bernard, ME and Kim, H and Berhane, H and Epperly, MW and Franicola, D and Zhang, X and Houghton, F and Shields, D and Wang, H and Bakkenist, CJ and Frantz, MC and Forbeck, EM and Goff, JP and Wipf, P and Greenberger, JS (2011) GS-nitroxide (JP4-039)-mediated radioprotection of human fanconi anemia cell lines. Radiation Research, 176 (5). 603 - 612. ISSN 0033-7587

Sharlow, ER and Wilson, GM and Close, D and Leimgruber, S and Tandon, M and Reed, RB and Shun, TY and Wang, QJ and Wipf, P and Lazo, JS (2011) Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity. PLoS ONE, 6 (10).

Botha, M and Chiang, AN and Needham, PB and Stephens, LL and Hoppe, HC and Külzer, S and Przyborski, JM and Lingelbach, K and Wipf, P and Brodsky, JL and Shonhai, A and Blatch, GL (2011) Plasmodium falciparum encodes a single cytosolic type i Hsp40 that functionally interacts with Hsp70 and is upregulated by heat shock. Cell Stress and Chaperones, 16 (4). 389 - 401. ISSN 1355-8145

Wipf, P and Manojlovic, MD (2011) Homoallylic amines by reductive inter- and intramolecular coupling of allenes and nitriles. Beilstein Journal of Organic Chemistry, 7. 824 - 830. ISSN 1860-5397

George, KM and Frantz, MC and Bravo-Altamirano, K and la Valle, CR and Tandon, M and Leimgruber, S and Sharlow, ER and Lazo, JS and Jane Wang, Q and Wipf, P (2011) Design, synthesis, and biological evaluation of PKD inhibitors. Pharmaceutics, 3 (2). 186 - 228.

Zaware, N and LaPorte, MG and Farid, R and Liu, L and Wipf, P and Floreancig, PE (2011) Diversity-oriented synthesis of a library of substituted tetrahydropyrones using oxidative carbon-hydrogen bond activation and click chemistry. Molecules, 16 (5). 3648 - 3662.

Huryn, DM and Brodsky, JL and Brummond, KM and Chambers, PG and Eyer, B and Ireland, AW and Kawasumi, M and LaPorte, MG and Lloyd, K and Manteau, B and Nghiem, P and Quade, B and Seguin, SP and Wipf, P (2011) Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators. Proceedings of the National Academy of Sciences of the United States of America, 108 (17). 6757 - 6762. ISSN 0027-8424

Kim, H and Bernard, ME and Epperly, MW and Shen, H and Amoscato, A and Dixon, TM and Doemling, AS and Li, S and Gao, X and Wipf, P and Wang, H and Zhang, X and Kagan, VE and Greenberger, JS (2011) Amelioration of radiation esophagitis by orally administered p53/Mdm2/Mdm4 inhibitor (BEB55) or GS-nitroxide. In Vivo, 25 (6). 841 - 848. ISSN 0258-851X

Goff, JP and Epperly, MW and Dixon, T and Wang, H and Franicola, D and Shields, D and Wipf, P and Li, S and Gao, X and Greenberger, JS (2011) Radiobiologic effects of GS-nitroxide (JP4-039) on the hematopoietic syndrome. In Vivo, 25 (3). 315 - 323. ISSN 0258-851X

Zuniga, JE and Hammill, JT and Drory, O and Nuss, JE and Burnett, JC and Gussio, R and Wipf, P and Bavari, S and Brunger, AT (2010) Iterative structure-based peptide-like inhibitor design against the botulinum neurotoxin serotype A. PLoS ONE, 5 (6).

Lavalle, CR and Bravo-Altamirano, K and Giridhar, KV and Chen, J and Sharlow, E and Lazo, JS and Wipf, P and Wang, QJ (2010) Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility. BMC Chemical Biology, 10.

Milner, E and McCalmont, W and Bhonsle, J and Caridha, D and Cobar, J and Gardner, S and Gerena, L and Goodine, D and Lanteri, C and Melendez, V and Roncal, N and Sousa, J and Wipf, P and Dow, GS (2010) Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols. Malaria Journal, 9 (1).

Xu, FL and Rbaibi, Y and Kiselyov, K and Lazo, JS and Wipf, P and Saunders, WS (2010) Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C<inf>1</inf>. BMC Chemical Biology, 10.

Epperly, MW and Goff, JP and Li, S and Gao, X and Wipf, P and Dixon, T and Wang, H and Franicola, D and Shen, H and Rwigema, JCM and Kagan, V and Bernard, M and Greenberger, JS (2010) Intraesophageal administration of GS-nitroxide (JP4-039) protects against ionizing irradiation-induced esophagitis. In Vivo, 24 (6). 811 - 819. ISSN 0258-851X

Epperly, MW and Franicola, D and Shields, D and Rwigema, JC and Stone, B and Zhang, X and Mcbride, W and Georges, G and Wipf, P and Greenberger, JS (2010) Screening of antimicrobial agents for in vitro radiation protection and mitigation capacity, including those used in supportive care regimens for bone marrow transplant recipients. In Vivo, 24 (1). 9 - 19. ISSN 0258-851X

Gokhale, A and Rwigema, JC and Epperly, MW and Glowacki, J and Wang, H and Wipf, P and Goff, JP and Dixon, T and Patrene, K and Greenberger, JS (2010) Small molecule GS-nitroxide ameliorates ionizing irradiation-induced delay in bone wound healing in a novel murine model. In Vivo, 24 (4). 377 - 385. ISSN 0258-851X

Sharlow, ER and Close, D and Shun, T and Leimgruber, S and Reed, R and Mustata, G and Wipf, P and Johnson, J and O'Neil, M and Grögl, M and Magill, AJ and Lazo, JS (2009) Identification of potent chemotypes targeting Leishmania major using a high-throughput, low-stringency, computationally enhanced, small molecule screen. PLoS Neglected Tropical Diseases, 3 (11).

Wipf, P and Xiao, J and Stephenson, CRJ (2009) Peptide-Like Molecules (PLMs): A journey from peptide bond isosteres to gramicidin s mimetics and mitochondrial targeting agents. Chimia, 63 (11). 764 - 775. ISSN 0009-4293

Fuller, AA and Du, D and Liu, F and Davoren, JE and Bhabha, G and Kroon, G and Case, DA and Dyson, HJ and Powers, ET and Wipf, P and Gruebele, M and Kelly, JW (2009) Evaluating β-turn mimics as β-sheet folding nucleators. Proceedings of the National Academy of Sciences of the United States of America, 106 (27). 11067 - 11072. ISSN 0027-8424

Johnston, PA and Foster, CA and Tierno, MB and Shun, TY and Shinde, SN and Paquette, WD and Brummond, KM and Wipf, P and Lazo, JS (2009) Cdc25B Dual-specificity phosphatase inhibitors identified in a high-throughput screen of the NIH compound library. Assay and Drug Development Technologies, 7 (3). 250 - 265. ISSN 1540-658X

Hopkins, CD and Wipf, P (2009) Isolation, biology and chemistry of the disorazoles: New anti-cancer macrodiolides. Natural Product Reports, 26 (5). 585 - 601. ISSN 0265-0568

Wright, CM and Seguin, SP and Fewell, SW and Zhang, H and Ishwad, C and Vats, A and Lingwood, CA and Wipf, P and Fanning, E and Pipas, JM and Brodsky, JL (2009) Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen. Virus Research, 141 (1). 71 - 80. ISSN 0168-1702

Chiang, AN and Valderramos, JC and Balachandran, R and Chovatiya, RJ and Mead, BP and Schneider, C and Bell, SL and Klein, MG and Huryn, DM and Chen, XS and Day, BW and Fidock, DA and Wipf, P and Brodsky, JL (2009) Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum. Bioorganic and Medicinal Chemistry, 17 (4). 1527 - 1533. ISSN 0968-0896

Rajagopalan, MS and Gupta, K and Epperly, MW and Franicola, D and Zhang, X and Wang, H and Zhao, H and Tyurin, VA and Pierce, JG and Kagan, VE and Wipf, P and Kanai, AJ and Greenberger, JS (2009) The mitochondria-targeted nitroxide JP4-039 augments potentially lethal irradiation damage repair. In Vivo, 23 (5). 717 - 726. ISSN 0258-851X

Sharlow, ER and Giridhar, KV and LaValle, CR and Chen, J and Leimgruber, S and Barrett, R and Bravo-Altamirano, K and Wipf, P and Lazo, JS and Wang, QJ (2008) Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone. Journal of Biological Chemistry, 283 (48). 33516 - 33526. ISSN 0021-9258

Rabu, C and Wipf, P and Brodsky, JL and High, S (2008) A precursor-specific role for Hsp40/Hsc70 during tail-anchored protein integration at the endoplasmic reticulum. Journal of Biological Chemistry, 283 (41). 27504 - 27513. ISSN 0021-9258

Liu, F and Du, D and Fuller, AA and Davoren, JE and Wipf, P and Kelly, JW and Gruebele, M (2008) An experimental survey of the transition between two-state and downhill protein folding scenarios. Proceedings of the National Academy of Sciences of the United States of America, 105 (7). 2369 - 2374. ISSN 0027-8424

Burnett, JC and Ruthel, G and Stegmann, CM and Panchal, RG and Nguyen, TL and Hermone, AR and Stafford, RG and Lane, DJ and Kenny, TA and McGrath, CF and Wipf, P and Stahl, AM and Schmidt, JJ and Gussio, R and Brunger, AT and Bavari, S (2007) Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons. Journal of Biological Chemistry, 282 (7). 5004 - 5014. ISSN 0021-9258

Levinson, N and Hinman, R and Patil, A and Stephenson, CRJ and Werner, S and Woo, GHC and Xiao, J and Wipf, P and Lynch, KW (2006) Use of transcriptional synergy to augment sensitivity of a splicing reporter assay. RNA, 12 (5). 925 - 930. ISSN 1355-8382

Fewell, SW and Smith, CM and Lyon, MA and Dumitrescu, TP and Wipf, P and Day, BW and Brodsky, JL (2004) Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity. Journal of Biological Chemistry, 279 (49). 51131 - 51140. ISSN 0021-9258

Wipf, P and Uto, Y and Yoshimura, S (2002) Total synthesis of a stereoisomer of bistramide C and assignment of configuration of the natural product. Chemistry (Weinheim an der Bergstrasse, Germany), 8 (7). ISSN 0947-6539

Ribe, S and Wipf, P (2001) Water-accelerated organic transformations. Chemical Communications (4). 299 - 307. ISSN 1359-7345

Wipf, P and Tsuchimoto, T and Takahashi, H (1999) Synthetic applications of ortho esters. Pure and Applied Chemistry, 71 (3). 415 - 421. ISSN 0033-4545