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Factors associated with invasive lung aspergillosis and the significance of positive aspergillus culture after liver transplantation

Kusne, S and Torre-Cisneros, J and Mañez, R and Irish, W and Martin, M and Fung, J and Simmons, RL and Starzl, TE (1992) Factors associated with invasive lung aspergillosis and the significance of positive aspergillus culture after liver transplantation. Journal of Infectious Diseases, 166 (6). 1379 - 1383. ISSN 0022-1899

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Abstract

From January 1981 to December 1990, 2180 patients underwent orthotopic liver transplantation at the University of Pittsburgh. Thirty-two patients (1.5%) were identified with invasive aspergillosis (29 lung, 2 intraabdominal, 1 meningitis). Of 29 patients with invasive lung disease, only 23 (79%) had positive culture (Aspergillus fumigatus, 20; Aspergillus flavus, 3). Forty-eight variables were analyzed and compared in 23 patients with invasive disease with positive cultures and 9 patients with colonization only. The variables associated with pulmonary invasive disease, by univariate analysis, were surgical time (P =.03), presence of laparotomies (P =.02), higher creatinine level at time of Aspergillus isolation (P =.01), and use of OKT3 (P =.02). However, in a multivariate analysis, only the last two (creatinine, OKT3) were associated with invasive lung aspergillosis. Of 4 patients with positive abdominal wound culture, 2 had local invasive aspergillosis. Therefore, positive cultures of Aspergillus organisms from respiratory secretions and wound drainage may represent invasive disease and should not be ignored. © 1992 the University of Chicago.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Kusne, S
Torre-Cisneros, J
Mañez, R
Irish, W
Martin, M
Fung, J
Simmons, RL
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1992
Date Type: Publication
Journal or Publication Title: Journal of Infectious Diseases
Volume: 166
Number: 6
Page Range: 1379 - 1383
DOI or Unique Handle: 10.1093/infdis/166.6.1379
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0022-1899
Other ID: uls-drl:31735062112481, Starzl CV No. 1455
Date Deposited: 08 Apr 2010 17:24
Last Modified: 04 Feb 2019 15:58
URI: http://d-scholarship.pitt.edu/id/eprint/4841

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