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The UW solution for canine kidney preservation: Its specific effect on renal hemodynamics and microvasculature

Ueda, Y and Todo, S and Imventarza, O and Furukawa, H and Oks, A and Wu, YM and Oguma, S and Starzl, TE (1989) The UW solution for canine kidney preservation: Its specific effect on renal hemodynamics and microvasculature. Transplantation, 48 (6). 913 - 918. ISSN 0041-1337

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Abstract

The preservation effects of UW solution on renal hemodynamics and microvascular systems were studied in canine kidney autografts. In 72-hr UW-preserved kidneys, the microvessels of both cortex and medulla were completely visualized with silicon rubber compound 1 hr after reperfusion. Histology also showed extremely well-preserved arterioglomerular and tubular systems. These results were correlated with good renal blood flow, prompt recovery of posttransplant graft function, and 100% two-week survival of dogs. In contrast, kidneys preserved for 72 hr with Euro-Collins solution showed necrotic and obstructive changes of the microvasculature and deterioration of renal hemodynamics. In 120-hr UW-preserved kidneys, the microcirculation of the medullary region became poor after reflow when there was fairly intact perfusion of the cortical region, indicating an ischemia-related intrarenal blood flow maldistribution. The 120-hr kidneys subsequently failed in spite of having a good blood flow and morphologically well-maintained microvasculature after reperfusion. These data demonstrated that much, but not all, of the beneficial effect of UW solution in kidney preservation might be attributed to its remarkable protection of renal microvasculature. Correction of intrarenal blood maldistribution caused by a discrepancy in tolerance to ischemia of the vascular and tubular systems might be important in successfully preserving the kidney for 120 hr. © 1989 by Williams & Wilkins.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Ueda, Y
Todo, S
Imventarza, O
Furukawa, H
Oks, A
Wu, YM
Oguma, S
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1989
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 48
Number: 6
Page Range: 913 - 918
DOI or Unique Handle: 10.1097/00007890-198912000-00004
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062110485, Starzl CV No. 1007
Date Deposited: 08 Apr 2010 17:17
Last Modified: 20 Jun 2020 14:55
URI: http://d-scholarship.pitt.edu/id/eprint/4393

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