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Beyond the dichotomy in vivo - in vitro: in silico

Garcia, Pio (2006) Beyond the dichotomy in vivo - in vitro: in silico. In: UNSPECIFIED. (Unpublished)


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From the beginnings of the biochemistry as discipline, the dichotomy between in vivo- in vitro conditions has been in the center of their methodological discussions. With the growing influence of computer simulations - sometimes called "in silico" conditions-, a new methodological problem is added to biochemistry. However, "simulation" could be seen as a core concept that is in fact used in the in vivo - in vitro dichotomy. In this sense, in silico dimension could be considered as a natural extension of the classical dichotomy. From the way in which simulation is used on in vivo-in vitro dichotomy, we also suggest that the general idea of simulation proposed by Hartmann have to be redefined. The intuitive idea of simulation resting on “imitation” relationship, as a “process that imitates another process” (Hartmann 1996), has to be complemented by others methodological concepts like “isolation” or “disruption”.

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Item Type: Conference or Workshop Item (UNSPECIFIED)
Garcia, Pio
Keywords: Simulation, Biochemistry
Subjects: General Issues > Models and Idealization
Depositing User: Pio Garcia
Date Deposited: 08 Jun 2006
Last Modified: 07 Oct 2010 15:14
Item ID: 2777
Public Domain: Yes
Subjects: General Issues > Models and Idealization
Date: 2006

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