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Scientific exploration of causation in biomedical research: The case of gene targeting on mouse embryonic stem cells

Chen, Ruey-Lin (2023) Scientific exploration of causation in biomedical research: The case of gene targeting on mouse embryonic stem cells. UNSPECIFIED.

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Abstract

This paper aims to explore scientific exploration of causation in biomedical science. “Scientific exploration” means searching for new information, data or knowledge beyond what is known about some objective by plural means. I use this concept in contrast to “scientific explanation,” because a scientific exploration does not answer a why-question. A scientific exploration is a scientific action or practice that involves not only exploratory experiments but also other means such as background knowledge and ideas, the production of research tools, standardized operational procedures, database searches, animal modeling, the realization of assumptions, and analogical reasoning. A scientific exploration of causation aims to discover new information, data or knowledge about a particular causal relationship. It can also determine whether a supposed causal relationship between a factor and a phenomenon exists or not. Hence, a scientific exploration of causation involves the establishment of a criterion of causation, which biomedical scientists frequently appeal to Robert Koch’s postulates. To flesh out a scientific exploration of causation, I offer a case study of gene targeting on mouse embryonic stem cells to illustrate, in particular, employing this technique to produce gene knockout mice that express the symptoms of cystic fibrosis and to establish a mouse model for human disease of cystic fibrosis.


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Item Type: Other
Creators:
CreatorsEmailORCID
Chen, Ruey-Linpyrlc@ccu.edu.tw0000-0001-8830-2254
Keywords: Scientific Exploration, Experimentation, Causation, Koch’s postulates, Gene-Targeting, Gene Knockout, Animal Models
Subjects: Specific Sciences > Biology > Molecular Biology/Genetics
General Issues > Causation
General Issues > Experimentation
Specific Sciences > Medicine > Health and Disease
Depositing User: Dr. Ruey-Lin Chen
Date Deposited: 08 Jul 2023 13:23
Last Modified: 08 Jul 2023 13:23
Item ID: 22291
Subjects: Specific Sciences > Biology > Molecular Biology/Genetics
General Issues > Causation
General Issues > Experimentation
Specific Sciences > Medicine > Health and Disease
Date: 14 July 2023
URI: https://philsci-archive-dev.library.pitt.edu/id/eprint/22291

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