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AVERAGE AND STANDARD DEVIATION OF THE ERROR FUNCTION FOR RANDOM GENETIC CODES WITH STANDARD STOP CODONS

Salinas, Dino (2021) AVERAGE AND STANDARD DEVIATION OF THE ERROR FUNCTION FOR RANDOM GENETIC CODES WITH STANDARD STOP CODONS. [Preprint]

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Abstract

The origin of the genetic code has been attributed in part to an accidental assignment of codons to amino acids. Although several lines of evidence indicate the subsequent expansion and improvement of the genetic code, the hypothesis of Francis Crick concerning a frozen accident occurring at the early stage of genetic code evolution is still widely accepted. Considering Crick’s hypothesis, mathematical descriptions of hypothetical scenarios involving a huge number of possible coexisting random genetic codes could be very important to explain the origin and evolution of a selected genetic code. This work aims to contribute in this regard, that is, it provides a theoretical framework in which statistical parameters of error functions are calculated. Given a genetic code and an amino acid property, the functional code robustness is estimated by means of a known error function. In this work, using analytical calculations, general expressions for the average and standard deviation of the error function distributions of completely random codes with standard stop codons were obtained. As a possible biological application of these results, any set of amino acids and any pure or mixed amino acid properties can be used in the calculations, such that, in case of having to select a set of amino acids to create a genetic code, possible advantages of natural selection of the genetic codes could be discussed.


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Item Type: Preprint
Creators:
CreatorsEmailORCID
Salinas, Dinodino.salinas@udp.cl0000-0001-8152-1622
Additional Information: This manuscript has been accepted for publication in Acta Biotheoretica.
Keywords: origin; evolution; genetic code; random; error function
Subjects: Specific Sciences > Biology > Evolutionary Theory
Specific Sciences > Biology > Molecular Biology/Genetics
General Issues > Computer Simulation
Specific Sciences > Probability/Statistics
Depositing User: Dr. Dino Salinas
Date Deposited: 28 Sep 2021 22:26
Last Modified: 28 Sep 2021 22:26
Item ID: 19627
Subjects: Specific Sciences > Biology > Evolutionary Theory
Specific Sciences > Biology > Molecular Biology/Genetics
General Issues > Computer Simulation
Specific Sciences > Probability/Statistics
Date: 27 May 2021
URI: https://philsci-archive-dev.library.pitt.edu/id/eprint/19627

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