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Rethinking the pragmatic systems biology and systems-theoretical biology divide: toward a complexity-inspired epistemology of systems biomedicine

Kesić, Srdjan (2019) Rethinking the pragmatic systems biology and systems-theoretical biology divide: toward a complexity-inspired epistemology of systems biomedicine. Medical hypotheses, 131. p. 109316.

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Abstract

This paper examines some methodological and epistemological issues underlying the ongoing “artificial” divide between pragmatic-systems biology and systems-theoretical biology. The pragmatic systems view of biology has encountered problems and constraints on its explanatory power because pragmatic systems biologists still tend to view systems as mere collections of parts, not as “emergent realities” produced by adaptive interactions between the constituting components. As such, they are incapable of characterizing the higher-level biological phenomena adequately. The attempts of systems-theoretical biologists to explain these “emergent realities” using mathematics also fail to produce satisfactory results.
Given the increasing strategic importance of systems biology, both from theoretical and research perspectives, we suggest that additional epistemological and methodological insights into the possibility of further integration between traditional experimental studies and complex modeling are required. This integration will help to improve the currently underdeveloped pragmatic-systems biology and system-theoretical biology.
The “epistemology of complexity,” I contend, acts as a glue that connects and integrates different and sometimes opposing viewpoints, perspectives, streams, and practices, thus maintaining intellectual and research coherence of systems research of life. It allows scientists to shift the focus from traditional experimental research to integrated, modeling-based holistic practices capable of providing a comprehensive knowledge of organizing principles of living systems. It also opens the possibility of the development of new practical and theoretical foundations of systems biology to build a better understanding of complex organismic functions.


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Item Type: Published Article or Volume
Creators:
CreatorsEmailORCID
Kesić, Srdjan
Keywords: Systems biology; Cybernetics; Second order cybernetics; Complexity; Complex biological systems; Epistemology of complexity;
Subjects: Specific Sciences > Biology
Specific Sciences > Biology > Molecular Biology/Genetics
General Issues > History of Philosophy of Science
General Issues > Structure of Theories
General Issues > Theory Change
Depositing User: Dr Srdjan Kesić
Date Deposited: 07 Aug 2021 23:50
Last Modified: 07 Aug 2021 23:50
Item ID: 19410
Journal or Publication Title: Medical hypotheses
Publisher: Churchill Livingstone
Official URL: https://www.sciencedirect.com/science/article/pii/...
DOI or Unique Handle: https://doi.org/10.1016/j.mehy.2019.109316
Subjects: Specific Sciences > Biology
Specific Sciences > Biology > Molecular Biology/Genetics
General Issues > History of Philosophy of Science
General Issues > Structure of Theories
General Issues > Theory Change
Date: October 2019
Page Range: p. 109316
Volume: 131
URI: https://philsci-archive-dev.library.pitt.edu/id/eprint/19410

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