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Aging biomarkers and the measurement of health and risk

Green, Sara and Hillersdal, Line (2021) Aging biomarkers and the measurement of health and risk. [Preprint]

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Abstract

Prevention of age-related disorders is increasingly in focus of health policies, and it is hoped that early intervention on processes of deterioration can promote healthier and longer lives. New opportunities to slow down the aging process are emerging with new fields such as personalized nutrition. Data-intensive research has the potential to improve the precision of existing risk factors, e.g., to replace coarse-grained markers such as blood cholesterol with more detailed multivariate biomarkers. In this paper, we follow an attempt to develop a new aging biomarker. The vision among the project consortium, comprising both research and industrial partners, is that the new biomarker will be predictive of a range of age-related conditions, which may be preventable through personalized nutrition. We combine philosophical analysis and ethnographic fieldwork to explore the possibilities and challenges of managing aging through bodily signs that are not straightforwardly linked to symptomatic disease. We document how the improvement of measurement brings about new conceptual challenges of demarcating healthy and unhealthy states. Moreover, we highlight that the reframing of aging as risk has social and ethical implications, as it is generative of normative notions of what constitutes successful aging and good citizenship.


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Item Type: Preprint
Creators:
CreatorsEmailORCID
Green, Sara
Hillersdal, Line
Keywords: Philosophy of aging; Aging biomarker; Medicalization; Healthy aging, Personalized nutrition
Subjects: Specific Sciences > Biology > Molecular Biology/Genetics
Specific Sciences > Medicine > Health and Disease
General Issues > Science and Policy
General Issues > Values In Science
Depositing User: Dr. Sara Green
Date Deposited: 26 Feb 2021 03:12
Last Modified: 26 Feb 2021 03:12
Item ID: 18753
DOI or Unique Handle: https://link.springer.com/article/10.1007%2Fs40656-021-00367-w
Subjects: Specific Sciences > Biology > Molecular Biology/Genetics
Specific Sciences > Medicine > Health and Disease
General Issues > Science and Policy
General Issues > Values In Science
Date: 2021
URI: https://philsci-archive-dev.library.pitt.edu/id/eprint/18753

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