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On the definition of a criterion of immunogenicity

Pradeu, T. and Carosella, E. D. (2006) On the definition of a criterion of immunogenicity. Proceedings of the National Academy of Sciences, 103 (47). pp. 17858-17861. ISSN 0027-8424


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The main objective of immunology is to establish why and when an immune response occurs, that is, to determine a criterion of immunogenicity. According to the consensus view, the proper criterion of immunogenicity lies in the discrimination between self and nonself. Here we challenge this consensus by suggesting a simpler and more comprehensive criterion, the criterion of continuity. Moreover, we show that this criterion may be considered as an interpretation of the immune “self.” We conclude that immunologists can continue to speak of the self, provided that they admit that the self/nonself discrimination is not an adequate criterion of immunogenicity.

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Item Type: Published Article or Volume
Pradeu, T.
Carosella, E. D.
Depositing User: Thomas Pradeu
Date Deposited: 19 Oct 2020 02:53
Last Modified: 19 Oct 2020 02:53
Item ID: 18275
Journal or Publication Title: Proceedings of the National Academy of Sciences
Official URL:
DOI or Unique Handle:
Date: 2006
Page Range: pp. 17858-17861
Volume: 103
Number: 47
ISSN: 0027-8424

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