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Constitutive immune mechanisms: mediators of host defence and immune regulation

Paludan, Søren R. and Pradeu, Thomas and Masters, Seth L. and Mogensen, Trine H. (2020) Constitutive immune mechanisms: mediators of host defence and immune regulation. Nature Reviews Immunology. ISSN 1474-1733


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The immune system enables organisms to combat infections and to eliminate endogenous challenges. Immune responses can be evoked through diverse inducible pathways. However, various constitutive mechanisms are also required for immunocompetence. The inducible responses of pattern recognition receptors of the innate immune system and antigen-specific receptors of the adaptive immune system are highly effective, but they also have the potential to cause extensive immunopathology and tissue damage, as seen in many infectious and autoinflammatory diseases. By contrast, constitutive innate immune mechanisms, including restriction factors, basal autophagy and proteasomal degradation, tend to limit immune responses, with loss-of-function mutations in these pathways leading to inflammation. Although they function through a broad and heterogeneous set of mechanisms, the constitutive immune responses all function as early barriers to infection and aim to minimize any disruption of homeostasis. Supported by recent human and mouse data, in this Review we compare and contrast the inducible and constitutive mechanisms of immunosurveillance.

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Item Type: Published Article or Volume
Paludan, Søren R.
Pradeu, Thomas
Masters, Seth L.
Mogensen, Trine H.
Depositing User: Thomas Pradeu
Date Deposited: 24 Oct 2020 19:49
Last Modified: 24 Oct 2020 19:49
Item ID: 18274
Journal or Publication Title: Nature Reviews Immunology
Official URL:
DOI or Unique Handle:
Date: 2020
ISSN: 1474-1733

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