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CRISPR-Cas immunity: beyond nonself and defence

Pradeu, Thomas and Moreau, Jean-Francois (2019) CRISPR-Cas immunity: beyond nonself and defence. Biology & Philosophy, 34 (1). ISSN 0169-3867


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In this commentary of Koonin’s target paper, we defend an extended view of CRISPR-Cas immunity by arguing that CRISPR-Cas includes, but cannot be reduced to, defence against nonself. CRISPR-Cas systems can target endogenous elements (for example in DNA repair) and tolerate exogenous elements (for example some phages). We conclude that the vocabulary of “defence” and “nonself” might be misleading when describing CRISPR-Cas systems.

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Item Type: Published Article or Volume
Pradeu, Thomas
Moreau, Jean-Francois
Depositing User: Thomas Pradeu
Date Deposited: 19 Oct 2020 02:48
Last Modified: 19 Oct 2020 02:48
Item ID: 18268
Journal or Publication Title: Biology & Philosophy
Official URL:
DOI or Unique Handle:
Date: 2019
Volume: 34
Number: 1
ISSN: 0169-3867

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