PhilSci Archive

Host-microbiota co-immunity : An intimate relationship that goes beyond defense Position paper for PTPBio

Bazin, T. and Chiu, L. and Pradeu, Thomas (2018) Host-microbiota co-immunity : An intimate relationship that goes beyond defense Position paper for PTPBio.

[img]
Preview
Text
Bazin-Chiu_Pradeu_Co-immunity_Position-paper-for-PTPBio_Final.pdf - Draft Version

Download (310kB) | Preview

Abstract

Resident microorganisms, known as the microbiota, are essential for many physiological functions
including protection against pathogens. Microbiota is indeed required for proper immune system
development and function, and can also host-independently protect against infections. Thus, a coconstructed view of host defense involving both host and microbiota, named “co-immunity”, has been
proposed, and the idea of an “immunological holobiont” has been suggested. Yet this view of coimmunity might be too limited, as experimental work has shown that the immune system is involved
in functions other than defense, essentially development and repair. Microbiota, through coimmunity, is thereby most likely involved in these functions, although strong evidence is currently
lacking. Moreover, as our point of view is mainly host-centered, we may miss the implications of coimmunity at broaderscales, including cellular and populational levels. Intriguingly, co-immunity effects
could be beneficial for one function and/or one level, while detrimental for others. All these elements
should be taken into consideration for microbiota manipulation, in order to avoid potentially harmful
side effects.


Export/Citation: EndNote | BibTeX | Dublin Core | ASCII/Text Citation (Chicago) | HTML Citation | OpenURL
Social Networking:
Share |

Item Type: Published Article or Volume
Creators:
CreatorsEmailORCID
Bazin, T.
Chiu, L.
Pradeu, Thomas
Depositing User: Thomas Pradeu
Date Deposited: 19 Oct 2020 02:47
Last Modified: 19 Oct 2020 02:47
Item ID: 18266
Date: 2018
URI: https://philsci-archive-dev.library.pitt.edu/id/eprint/18266

Monthly Views for the past 3 years

Monthly Downloads for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item