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The danger theory: 20 years later

Pradeu, Thomas and Cooper, Edwin L. (2012) The danger theory: 20 years later. Frontiers in Immunology, 3. ISSN 1664-3224


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The self–non-self theory has dominated immunology since the 1950s. In the 1990s, Matzinger and her colleagues suggested a new, competing theory, called the “danger theory.” This theory has provoked mixed acclaim: enthusiasm and criticism. Here we assess the danger theory vis-à-vis recent experimental data on innate immunity, transplantation, cancers and tolerance to foreign entities, and try to elucidate more clearly whether danger is well defined.

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Item Type: Published Article or Volume
Pradeu, Thomas
Cooper, Edwin L.
Depositing User: Thomas Pradeu
Date Deposited: 18 Oct 2020 02:34
Last Modified: 18 Oct 2020 02:34
Item ID: 18244
Journal or Publication Title: Frontiers in Immunology
Official URL:
DOI or Unique Handle:
Date: 2012
Volume: 3
ISSN: 1664-3224

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