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What and How do Cancer Systems Biologists Explain?

Plutynski, Anya and Bertolaso, Marta (2018) What and How do Cancer Systems Biologists Explain? [Preprint]

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Abstract

In this article, we argue, first, that there are very different research projects that fall under the heading of “systems biology of cancer.” While they share some general features, they differ in their aims and theoretical commitments. Second, we argue that some explanations in systems biology of cancer are concerned with properties of signaling networks (such as robustness or fragility) and how they may play an important causal role in patterns of vulnerability to cancer. Further, some systems biological explanations are compelling illustrations of how “top-down” and “bottom-up” approaches to the same phenomena
may be integrated.


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Item Type: Preprint
Creators:
CreatorsEmailORCID
Plutynski, Anyaaplutyns@wustl.edu
Bertolaso, Martam.bertolaso@unicampus.it
Keywords: systems biology, cancer, explanation, integration, networks
Subjects: Specific Sciences > Biology
Specific Sciences > Biology > Molecular Biology/Genetics
General Issues > Explanation
Depositing User: A Plutynski
Date Deposited: 16 Dec 2019 00:45
Last Modified: 16 Dec 2019 00:45
Item ID: 16726
Subjects: Specific Sciences > Biology
Specific Sciences > Biology > Molecular Biology/Genetics
General Issues > Explanation
Date: December 2018
URI: https://philsci-archive-dev.library.pitt.edu/id/eprint/16726

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