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Re-thinking our understanding of immunity: Robustness in the tissue reconstruction system

Truchetet, Marie-Elise and Pradeu, Thomas (2018) Re-thinking our understanding of immunity: Robustness in the tissue reconstruction system. Seminars in Immunology, 36. pp. 45-55. ISSN 10445323

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Abstract

Robustness, understood as the maintenance of specific functionalities of a given system against internal and external perturbations, is pervasive in today's biology. Yet precise applications of this notion to the immune system have been scarce. Here we show that the concept of robustness sheds light on tissue repair, and particularly on the crucial role the immune system plays in this process. We describe the specific mechanisms, including plasticity and redundancy, by which robustness is achieved in the tissue reconstruction system (TRS). In turn, tissue repair offers a very important test case for assessing the usefulness of the concept of robustness, and identifying different varieties of robustness.


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Item Type: Published Article or Volume
Creators:
CreatorsEmailORCID
Truchetet, Marie-Elise
Pradeu, Thomas
Keywords: Plasticity; Redundancy; Robustness; Surveillance; Tissue regeneration; Tissue repair
Subjects: Specific Sciences > Biology
Specific Sciences > Biology > Developmental Biology
Specific Sciences > Biology > Evolutionary Theory
Specific Sciences > Biology > Function/Teleology
Specific Sciences > Biology > Molecular Biology/Genetics
Specific Sciences > Medicine > Health and Disease
Specific Sciences > Medicine
Depositing User: Thomas Pradeu
Date Deposited: 28 Oct 2019 02:35
Last Modified: 28 Oct 2019 02:35
Item ID: 16591
Journal or Publication Title: Seminars in Immunology
Official URL: http://doi.org/10.1016/j.smim.2018.02.013
DOI or Unique Handle: https://doi.org/10.1016/j.smim.2018.02.013
Subjects: Specific Sciences > Biology
Specific Sciences > Biology > Developmental Biology
Specific Sciences > Biology > Evolutionary Theory
Specific Sciences > Biology > Function/Teleology
Specific Sciences > Biology > Molecular Biology/Genetics
Specific Sciences > Medicine > Health and Disease
Specific Sciences > Medicine
Date: 2018
Page Range: pp. 45-55
Volume: 36
ISSN: 10445323
URI: https://philsci-archive-dev.library.pitt.edu/id/eprint/16591

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