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Immunological memory: What's in a name?

Pradeu, Thomas and Du Pasquier, Louis (2018) Immunological memory: What's in a name? Immunological Reviews, 283 (1). pp. 7-20. ISSN 01052896

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Abstract

Immunological memory is one of the core topics of contemporary immunology. Yet there are many discussions about what this concept precisely means, which components of the immune system display it, and in which phyla it exists. Recent years have seen the multiplication of claims that immunological memory can be found in "innate" immune cells and in many phyla beyond vertebrates (including invertebrates, plants, but also bacteria and archaea), as well as the multiplication of concepts to account for these phenomena, such as "innate immune memory" or "trained immunity". The aim of this critical review is to analyze these recent claims and concepts, and to distinguish ideas that have often been misleadingly associated, such as memory, adaptive immunity, and specificity. We argue that immunological memory is a gradual and multidimensional phenomenon, irreducible to any simple dichotomy, and we show why adopting this new view matters from an experimental and therapeutic point of view.


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Item Type: Published Article or Volume
Creators:
CreatorsEmailORCID
Pradeu, Thomas
Du Pasquier, Louis
Keywords: evolution; innate immunity; lymphocytes; priming; somatic recombination; trained immunity
Subjects: Specific Sciences > Biology
Specific Sciences > Biology > Developmental Biology
Specific Sciences > Biology > Evolutionary Theory
Specific Sciences > Biology > Function/Teleology
Specific Sciences > Biology > Molecular Biology/Genetics
Specific Sciences > Medicine > Health and Disease
Specific Sciences > Medicine
Depositing User: Thomas Pradeu
Date Deposited: 28 Oct 2019 02:36
Last Modified: 28 Oct 2019 02:36
Item ID: 16590
Journal or Publication Title: Immunological Reviews
Official URL: http://doi.org/10.1111/imr.12652
DOI or Unique Handle: https://doi.org/10.1111/imr.12652
Subjects: Specific Sciences > Biology
Specific Sciences > Biology > Developmental Biology
Specific Sciences > Biology > Evolutionary Theory
Specific Sciences > Biology > Function/Teleology
Specific Sciences > Biology > Molecular Biology/Genetics
Specific Sciences > Medicine > Health and Disease
Specific Sciences > Medicine
Date: 2018
Page Range: pp. 7-20
Volume: 283
Number: 1
ISSN: 01052896
URI: https://philsci-archive-dev.library.pitt.edu/id/eprint/16590

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