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The Multiple Layers of the Tumor Environment

Laplane, Lucie and Duluc, Dorothée and Larmonier, Nicolas and Pradeu, Thomas and Bikfalvi, Andreas (2018) The Multiple Layers of the Tumor Environment. Trends in Cancer, 4 (12). pp. 802-809. ISSN 24058033

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Abstract

The notion of tumor microenvironment (TME) has been brought to the forefront of recent scientific literature on cancer. However, there is no consensus on how to define and spatially delineate the TME. We propose that the time is ripe to go beyond an all-encompassing list of the components of the TME, and to construct a multilayered view of cancer. We distinguish six layers of environmental interactions with the tumor and show that they are associated with distinct mechanisms, and ultimately with distinct therapeutic approaches.


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Item Type: Published Article or Volume
Creators:
CreatorsEmailORCID
Laplane, Lucie
Duluc, Dorothée
Larmonier, Nicolas
Pradeu, Thomas
Bikfalvi, Andreas
Keywords: angiogenesis; immune system; niche; tumor microenvironment; tumor organismal environment
Subjects: Specific Sciences > Biology
Specific Sciences > Biology > Developmental Biology
Specific Sciences > Biology > Molecular Biology/Genetics
Specific Sciences > Medicine > Health and Disease
Specific Sciences > Medicine
Depositing User: Thomas Pradeu
Date Deposited: 28 Oct 2019 02:38
Last Modified: 28 Oct 2019 02:38
Item ID: 16588
Journal or Publication Title: Trends in Cancer
Official URL: http://doi.org/10.1016/j.trecan.2018.10.002
DOI or Unique Handle: https://doi.org/10.1016/j.trecan.2018.10.002
Subjects: Specific Sciences > Biology
Specific Sciences > Biology > Developmental Biology
Specific Sciences > Biology > Molecular Biology/Genetics
Specific Sciences > Medicine > Health and Disease
Specific Sciences > Medicine
Date: 2018
Page Range: pp. 802-809
Volume: 4
Number: 12
ISSN: 24058033
URI: https://philsci-archive-dev.library.pitt.edu/id/eprint/16588

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