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Dissolving the Missing Heritability Problem

Bourrat, Pierrick and Lu, Qiaoying (2017) Dissolving the Missing Heritability Problem. [Preprint]

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Abstract

Heritability estimates obtained from genome-wide association studies (GWAS) are much lower than those of traditional quantitative methods. This phenomenon has been called the
“missing heritability problem.” By analyzing and comparing GWAS and traditional quantitative methods, we fi rst show that the estimates obtained from the latter involve some terms other than additive genetic variance, while the estimates from the former do not. Second, GWAS, when used to estimate heritability, do not take into account additive epigenetic factors transmitted across generations, while traditional quantitative methods do. Given these two points we show that the missing heritability problem can largely be dissolved.


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Item Type: Preprint
Creators:
CreatorsEmailORCID
Bourrat, Pierrickp.bourrat@gmail.com
Lu, Qiaoying
Subjects: Specific Sciences > Biology
Specific Sciences > Biology > Evolutionary Theory
Specific Sciences > Biology > Molecular Biology/Genetics
Depositing User: Mr Pierrick Bourrat
Date Deposited: 17 Dec 2017 20:54
Last Modified: 17 Dec 2017 20:54
Item ID: 14215
Journal or Publication Title: Philosophy of Science
Official URL: http://www.journals.uchicago.edu/doi/pdfplus/10.10...
Subjects: Specific Sciences > Biology
Specific Sciences > Biology > Evolutionary Theory
Specific Sciences > Biology > Molecular Biology/Genetics
Date: 5 December 2017
URI: https://philsci-archive-dev.library.pitt.edu/id/eprint/14215

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