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Evidence, illness, and causation: an epidemiological perspective on the Russo-Williamson Thesis.

Fiorentino, Alexander R and Dammann, Olaf (2015) Evidence, illness, and causation: an epidemiological perspective on the Russo-Williamson Thesis. Studies in history and philosophy of biological and biomedical sciences, 54. pp. 1-9. ISSN 1879-2499

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Abstract

According to the Russo-Williamson Thesis, causal claims in the health sciences need to be supported by both difference-making and mechanistic evidence. In this article, we attempt to determine whether Evidence-based Medicine (EBM) can be improved through the consideration of mechanistic evidence. We discuss the practical composition and function of each RWT evidence type and propose that exposure-outcome evidence (previously known as difference-making evidence) provides associations that can be explained through a hypothesis of causation, while mechanistic evidence provides finer-grained associations and knowledge of entities that ultimately explains a causal hypothesis. We suggest that mechanistic evidence holds untapped potential to add value to the assessment of evidence quality in EBM and propose initial recommendations for the integration of mechanistic and exposure-outcome evidence to improve EBM by robustly leveraging available evidence in support of good medical decisions.


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Item Type: Published Article or Volume
Creators:
CreatorsEmailORCID
Fiorentino, Alexander R
Dammann, Olaf
Subjects: General Issues > Causation
General Issues > Explanation
Specific Sciences > Medicine
Depositing User: Dr. Olaf Dammann
Date Deposited: 12 Aug 2016 19:59
Last Modified: 12 Aug 2016 19:59
Item ID: 12355
Journal or Publication Title: Studies in history and philosophy of biological and biomedical sciences
Subjects: General Issues > Causation
General Issues > Explanation
Specific Sciences > Medicine
Date: December 2015
Page Range: pp. 1-9
Volume: 54
ISSN: 1879-2499
URI: https://philsci-archive-dev.library.pitt.edu/id/eprint/12355

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