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Judging Quality and Coordination in Biomarker Diagnostic Development

Hey, Spencer Phillips (2015) Judging Quality and Coordination in Biomarker Diagnostic Development. THEORIA. An International Journal for Theory, History and Foundations of Science, 30 (2). pp. 207-227. ISSN 2171-679X

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Abstract

What makes a high-quality biomarker experiment The success of personalised medicine hinges on the answer to this question. In this paper, I argue that judgment about the quality of biomarker experiments is mediated by the problem of theoretical underdetermination. That is, the network of biological and pathophysiological theories motivating a biomarker experiment is sufficiently complicated that it often frustrates valid interpretation of the experimental results. Drawing on a case-study in biomarker diagnostic development from neurooncology, I argue that this problem of underdetermination can be overcome with greater coordination across the biomarker research trajectory. I then sketch an account for how coordination across a research trajectory can be evaluated. I ultimate conclude that what makes a high-quality biomarker experiment must be judged by the epistemic contribution it makes to this coordinated research effort.


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Item Type: Published Article or Volume
Creators:
CreatorsEmailORCID
Hey, Spencer Phillipsspencer.hey@mcgill.ca
Additional Information: ISSN: 0495-4548 (print)
Keywords: biomarkers; personalised medicine; underdetermination; neurooncology
Subjects: Specific Sciences > Biology
General Issues > Experimentation
Specific Sciences > Medicine
Depositing User: Unnamed user with email theoria@ehu.es
Date Deposited: 07 Jun 2016 13:08
Last Modified: 07 Jun 2016 13:08
Item ID: 12147
Journal or Publication Title: THEORIA. An International Journal for Theory, History and Foundations of Science
Publisher: Euskal Herriko Unibertsitatea / Universidad del País Vasco
Official URL: http://www.ehu.eus/ojs/index.php/THEORIA/article/v...
DOI or Unique Handle: https://doi.org/10.1387/theoria.12697
Subjects: Specific Sciences > Biology
General Issues > Experimentation
Specific Sciences > Medicine
Date: May 2015
Page Range: pp. 207-227
Volume: 30
Number: 2
ISSN: 2171-679X
URI: https://philsci-archive-dev.library.pitt.edu/id/eprint/12147

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