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Crucial Stem Cell Experiments? Stem Cells, Uncertainty, and Single-Cell Experiments

Fagan, Melinda B. (2015) Crucial Stem Cell Experiments? Stem Cells, Uncertainty, and Single-Cell Experiments. THEORIA. An International Journal for Theory, History and Foundations of Science, 30 (2). pp. 183-205. ISSN 2171-679X

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Abstract

I have previously argued that stem cell experiments cannot demonstrate that a single cell is a stem cell (Fagan 2013a, b). Laplane and others dispute this claim, citing experiments that identify stem cells at the single-cell level. This paper rebuts the counterexample, arguing that the alleged ‘crucial stem cell experiments’ do not measure self-renewal for a single cell, do not establish a single cell’s differentiation potential, and, if interpreted as providing results about single cells, fall into epistemic circularity. I then discuss the source of the dispute, locating it in differences between philosophical and experimental perspectives.


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Item Type: Published Article or Volume
Creators:
CreatorsEmailORCID
Fagan, Melinda B.mel.fagan@utah.edu
Additional Information: ISSN: 0495-4548 (print)
Keywords: experiment; stem cells; models; crucial experiments; in vivo/in vitro
Subjects: Specific Sciences > Biology
General Issues > Experimentation
General Issues > History of Science Case Studies
General Issues > Models and Idealization
Depositing User: Unnamed user with email theoria@ehu.es
Date Deposited: 07 Jun 2016 13:09
Last Modified: 07 Jun 2016 13:09
Item ID: 12146
Journal or Publication Title: THEORIA. An International Journal for Theory, History and Foundations of Science
Publisher: Euskal Herriko Unibertsitatea / Universidad del País Vasco
Official URL: http://www.ehu.eus/ojs/index.php/THEORIA/article/v...
DOI or Unique Handle: https://doi.org/10.1387/theoria.12707
Subjects: Specific Sciences > Biology
General Issues > Experimentation
General Issues > History of Science Case Studies
General Issues > Models and Idealization
Date: May 2015
Page Range: pp. 183-205
Volume: 30
Number: 2
ISSN: 2171-679X
URI: https://philsci-archive-dev.library.pitt.edu/id/eprint/12146

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