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Effect of preoperative thoracic duct drainage on canine kidney transplantation

Funakoshi, Y and Carrieri, G and Yagihashi, A and Iwaki, Y and Todo, S and Starzl, TE (1996) Effect of preoperative thoracic duct drainage on canine kidney transplantation. Journal of Investigative Surgery, 9 (5). 359 - 367. ISSN 0894-1939

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Abstract

Chronic drainage of the thoracic duct to the esophagus was developed in dogs, and its efficacy in immunomodulation was tested using kidney transplantation. Compared to 9.7 days in the control, the mean animal survival was prolonged to 9.9 days, 17.8 days, and 18.5 days when TDD was applied preoperatively for 3 weeks, 6 weeks, and 9 weeks, respectively. Prolongation was significant after 6 weeks. Patency of the fistula was 93.5, 80.4, and 76.1% at respective weeks. Number of peripheral T-lymphocytes determined by a new monoclonal antibody diminished after 3 weeks. All animals were in normal health, requiring no special care for fluid, electrolyte, or protein replacement.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Funakoshi, Y
Carrieri, G
Yagihashi, A
Iwaki, Y
Todo, S
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1996
Date Type: Publication
Journal or Publication Title: Journal of Investigative Surgery
Volume: 9
Number: 5
Page Range: 359 - 367
DOI or Unique Handle: 10.3109/08941939609021277
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0894-1939
Other ID: uls-drl:31735062126994, Starzl CV No. 1977
Date Deposited: 08 Apr 2010 17:33
Last Modified: 02 Feb 2019 13:55
URI: http://d-scholarship.pitt.edu/id/eprint/5363

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